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Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the Cannabis sativa plant, often referred to as the "mother of all cannabinoids" because it is the precursor from which other cannabinoids are synthesized. Unlike THC and CBD, CBG is typically present in low concentrations in most cannabis strains. CBG interacts uniquely with the body's endocannabinoid system (ECS), particularly with the CB1–CB2 heteromer receptor complex, which may influence various physiological processes. Additionally, CBG has shown affinity for receptors such as 5-HT1A, α-2 adrenoceptor, PPARγ, and GPR55, suggesting potential therapeutic applications in mood regulation, inflammation, metabolic disorders, and pain perception. While research into CBG's effects is ongoing, its non-psychoactive nature and diverse receptor interactions make it a promising candidate for further study.