F30A Journal — Endocannabinoid System

Introduction Cannabigerol (CBG), a non-psychoactive cannabinoid found in the Cannabis sativa plant, is gaining attention in the scientific community for its potential therapeutic benefits. Unlike its more famous counterparts, THC and CBD, CBG is often referred to as the "mother of all cannabinoids" due to a common misconception about its role as a precursor from which other cannabinoids are synthesized (these cannabinoids are synthesized from CBGA, the acidic form of CBG, from which CBG is itself synthesized). This article delves into the effects, benefits, and legal status of CBG, with a particular focus on its interaction with various receptor sites...

The endocannabinoid system (ECS) is a complex signaling network of receptors, enzymes, and endocannabinoids that helps regulate various physiological processes, including reproduction. The ECS is composed of cannabinoid receptors (CB₁, CB₂, and GPR55 are the most common), endogenous ligands (endocannabinoids), and enzymes responsible for endocannabinoid synthesis and degradation. Recent research has highlighted the significant impact of the ECS on the female reproductive system, affecting fertility, pregnancy, and other reproductive functions. Endocannabinoids are naturally occurring molecules that bind to cannabinoid receptors in the body, including CB₁ and CB₂ receptors. CB₁ receptors are highly expressed in the female reproductive system, including the...

The use of compounded bioidentical hormone replacement was originally developed in 1939 for women who had undergone radical hysterectomies. The longest-studied type of hormone replacement therapy (or HRT as it is commonly known), it was primarily utilized in Europe and Australia until about 2011, when innovators in the field of integrative and functional medicine started reintroducing the therapy into the United States. A reintroduction made necessary by HRT’s controversial path to acceptance. n the United States, hormone replacement therapy began in the 1960s and later gained traction in the 1990s with The Women’s Health Initiative, a long-term national health study...

In our fast paced, perfection driven culture it is getting harder and harder for men to meet the sometimes-unrealistic expectations they and others put on themselves. It definitely is no coincidence that there are supplements targeting men’s stamina and energy issues as products that boost testosterone on every major channel and various advertising outlets. They know there is an interest, but, more importantly, there is a NEED!As the world is changing with ever-increasing demands on time, there is less reserve for men’s bodies to feel optimized. As we have less time to exercise… As we make poor food choices because...